Hemoglobin H Associated with an Uncommon Variant of Thalassemia Trait
نویسندگان
چکیده
منابع مشابه
Hemoglobin H associated with an uncommon variant of thalassemia trait.
I N 1955 RIGAS ET AL.1 and Gouttas et al.2 independently reported the discovery of a new hemoglobin characterized electrophoretically at pH 8.6 by a more rapid anodal mobility than that of normal adult hemoglobin. This hemoglobin has subsequently been identified by the letter “H.” More recently, “fast” hemoglobins other than “H” have been described. These include hemoglobins J,3 J,4-1#{176} K,5...
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Hemoglobin (Hb) North Shore (beta 134 val leads to glu) is a mutant hemoglobin that is associated with the phenotype of mild heterozygous beta-thalassemia. Heterozygotes are characterized low normal hemoglobin levels or mild anemia, microcytosis, increased HbA2, and 34%-38% Hb North Shore. The mechanism of the anemia and microcytosis associated with Hb North Shore was explored by studies of hem...
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Despite the vast heterogeneity of mutations, the levels of increased hemoglobin (Hb) A2 seen in individuals of different racial groups heterozygous for the different P-thalassemia mutations are remarkably uniform and rarely more than 6%. However, unusually high levels of Hb A2 have been observed in some P-thalassemia heterozygotes; in one group, it is associated with a partial or complete delet...
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ژورنال
عنوان ژورنال: Blood
سال: 1960
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v16.1.975.975